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What is the physiological cause of the fourth heart sound in patients with advanced aortic stenosis?

Atrial contraction against a noncompliant left ventricle

The fourth heart sound, also known as S4, is commonly associated with atrial contraction. In the context of advanced aortic stenosis, the correct answer reflects a key physiological mechanism.

In advanced aortic stenosis, the left ventricle becomes hypertrophied and less compliant due to the increased pressure overload it experiences trying to eject blood through the narrowed aortic valve. As a result, when the atria contract and push blood into the ventricle, this contraction happens against a stiff or noncompliant left ventricle. This leads to the characteristic low-frequency sound of S4, which indicates that the atrial contraction is occurring in a ventricle that cannot easily accommodate the incoming blood.

The other options do not accurately describe the cause of S4 in this setting. Blood striking a dilated left ventricle during diastole might produce sounds but is not the hallmark sound associated with the stiff ventricle present in aortic stenosis. Delayed closure of the aortic valve refers to a timing issue rather than a sound produced by atrial contraction against a noncompliant ventricle. Lastly, turbulent blood flow, while significant in aortic stenosis, typically relates to the aortic murmur

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Blood striking a dilated left ventricle during diastole

Delayed closure of the aortic valve in relation to the pulmonic valve

Turbulent blood flow across a calcified aortic valve

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